PD-L1 inhibitor 4

Names

[ Name ]:
PD-L1 inhibitor 4

Biological Activity

[Description]:

PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.PD-L1 inhibitor 4 exhibited substantially increased binding affinity to hPD-L1, as well as PD-1/PD-L1 inhibitory activity in physiological conditions.PD-L1 inhibitor 4 also showed a dose-dependent increase in IFN-γ secretion levels in a mixed lymphocyte reaction assay.

[References]

1. Kawashita S, et al. Bioorg Med Chem Lett. 2019 Sep 1;29(17):2464-2467.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀H₄₈N₆O₁₀

[ Molecular Weight ]:
892.966

Related Compounds

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