ABBV-712

Names

[ Name ]:
ABBV-712

Biological Activity

[Description]:

ABBV-712 is a selective inhibitor of Tyrosine kinase 2 (TYK2), with IC50 of 0.195 μM, that play important role in autoimmune diseases[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

JAK1:80 μM (IC50)

[References]

[1]. Eric Breinlinger, et al. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J Med Chem. 2023 Oct 26;66(20):14335-14356.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₈N₄O₅

[ Molecular Weight ]:
452.50

Related Compounds

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