NBD-125

Names

[ CAS No. ]:
2367641-24-3

[ Name ]:
NBD-125

Biological Activity

[Description]:

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RXRα

[In Vitro]

NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1]. NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1]. Western Blot Analysis[1] Cell Line: Km12c, HCT116 and SW620 cell lines. Concentration: 0-50 μM, 0-60, 0-80 μM. Incubation Time: 15 h. Result: Downregulated c-Myc, Cdc42 protein levels.

[References]

[1]. Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63(11):5841-5855.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₈ClNO₂

[ Molecular Weight ]:
327.80

NBD-125

Names

Biological Activity

Chemical & Physical Properties

Related Compounds