Methyl thioglycolate
Names
[ CAS No. ]:
2365-48-2
[ Name ]:
Methyl thioglycolate
[Synonym ]:
methylthioglycolic ester
Acetic acid, 2-mercapto-, methyl ester
mercapto acetic acid methylester
2-mercaptoacetic acid methyl ester
USAF EK-7119
Methyl Thioglycolate
methyl mercaptoglycolate
methyl 2-mercaptoacetate
Methyl sulfanylacetate
EINECS 219-121-7
Methanethiol,methoxy
Mercaptoacetic Acid Methyl Ester
Acetic acid,mercapto-,methyl ester
Methylthioglycolate
Thioglycolic acid methyl ester
MFCD00004873
Methyl mercaptoacetate
UNII:O1608LA9EL
sulfanylacetic acid methyl ester
1-methoxycarbonylmethanethiol
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
151.9±0.0 °C at 760 mmHg
[ Melting Point ]:
-24 °C
[ Molecular Formula ]:
C3H6O2S
[ Molecular Weight ]:
106.144
[ Flash Point ]:
35.0±7.8 °C
[ Exact Mass ]:
106.008850
[ PSA ]:
65.10000
[ LogP ]:
0.65
[ Vapour Pressure ]:
3.6±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.449
[ Water Solubility ]:
40 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AI7350000
- CHEMICAL NAME :
- Acetic acid, mercapto-, methyl ester
- CAS REGISTRY NUMBER :
- 2365-48-2
- BEILSTEIN REFERENCE NO. :
- 0506259
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C3-H6-O2-S
- MOLECULAR WEIGHT :
- 106.15
- WISWESSER LINE NOTATION :
- SH1VO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Skin and Appendages - hair
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570921
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 252 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,575,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1100 mg/kg/15D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570921
Safety Information
[ Symbol ]:
GHS02, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H301-H315-H319-H332-H335
[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;Xn:Harmful;
[ Risk Phrases ]:
R10;R20/22;R25;R36/37/38
[ Safety Phrases ]:
S26-S36/37-S45-S36/37/39-S28A
[ RIDADR ]:
UN 1992 3/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
AI7350000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
29309070
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Small 10(24) , 5137-50, (2014)
The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Here, a transactivator of tran...
Ligand-controlled growth of ZnSe quantum dots in water during Ostwald ripening.Langmuir 28(36) , 12931-40, (2012)
A strong ligand effect was observed for the aqueous-phase growth of ZnSe quantum dots (QDs) in the Ostwald ripening (OR) stage. The QDs were made by injecting Se monomer at room temperature followed b...
Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography/mass spectrometry.Rapid Commun. Mass Spectrom. 13(5) , 350-3, (1999)
A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) ...