STING agonist-23

STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

Research Areas >> Infection

Signaling Pathways >> Immunology/Inflammation >> STING

STING agonist-23 (10 μM；3 小时或 5 小时) 处理 THP-1 细胞 3 小时后，增加磷酸化 STING、TBK1 和 IRF3 的水平；处理 THP-1 细胞 5 小时后，增加 IFN-β、IL-6、CXCL-10、TNF-α、ISG-15 和 CCL-5 的含量[1]。

STING agonist-23 佐剂 (20μg STING agonist-23+5μg RBD-Fc/小鼠；肌肉注射；每 14 天间隔 3 次) 在小鼠模型中增强由 SARS-CoV-2 RBD-Fc 蛋白诱导的强烈抗体免疫反应[1]。

[1]. Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32(3):269-287.