CCW16

Names

[ Name ]:
CCW16

[Synonym ]:
Acetamide, 2-chloro-N-[4-(4-methoxyphenoxy)phenyl]-N-(phenylmethyl)-
N-Benzyl-2-chloro-N-[4-(4-methoxyphenoxy)phenyl]acetamide

Biological Activity

[Description]:

CCW16 is the covalent ligand for the E3 ubiquitin ligase RNF4. CCW16 can be used in the synthesis of protein degraders[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Ward CC, et, al. Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
533.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀ClNO₃

[ Molecular Weight ]:
381.852

[ Flash Point ]:
276.3±30.1 °C

[ Exact Mass ]:
381.113159

[ LogP ]:
3.66

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds

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