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8-debenzoylpaeoniflorin

Names

[ CAS No. ]:
23532-11-8

[ Name ]:
8-debenzoylpaeoniflorin

[Synonym ]:
β-D-Glucopyranoside, (1aR,2S,3aR,5R,5aR,5bS)-tetrahydro-5-hydroxy-5b-(hydroxymethyl)-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl
(1R,2S,3R,5R,6R,8S)-6-Hydroxy-2-(hydroxymethyl)-8-methyl-9,10-dioxatetracyclo[4.3.1.02,5.03,8]dec-3-yl β-D-glucopyranoside

Biological Activity

[Description]:

8-Debenzoylpaeoniflorin, a monoterpene glycoside, is a natural product that could be isolated from the dried root of Paeonia lactiflora Pall. 8-Debenzoylpaeoniflorin has antihyperglycemic activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vivo]

8-Debenzoylpaeoniflorin (1-10 mg/kg; i.v.; 单次注射) 具有抗高血糖活性，并降低 stz-糖尿病大鼠的血糖水平[1]。 Animal Model: Male Wistar STZ-diabetic rats (210-250g)[1] Dosage: 1, 5, and 10 mg/kg Administration: Intravenous injection, single dose Result: Decreased plasma glucose levels in a time- and dose-dependent manner in STZ-diabetic rats.

[References]

[1]. Hsu FL, et, al. Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Med. 1997 Aug;63(4):323-5.  

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
626.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H24O10

[ Molecular Weight ]:
376.356

[ Flash Point ]:
332.9±31.5 °C

[ Exact Mass ]:
376.136932

[ LogP ]:
-2.64

[ Vapour Pressure ]:
0.0±4.2 mmHg at 25°C

[ Index of Refraction ]:
1.695

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds