<Suppliers Price>

JMS-17-2 hydrochloride

Names

[ CAS No. ]:
2341841-07-2

[ Name ]:
JMS-17-2 hydrochloride

Biological Activity

[Description]:

JMS-17-2 hydrochloride is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 hydrochloride impairs metastatic seeding and colonization of breast cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> Others >> Others

[Target]

IC50: 0.32 nM (CX3CR1)[1]


[In Vivo]

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice[1]. Animal Model: SCID mice (~25g) with MDA-231 xenograft[1] Dosage: 10 mg/kg Administration: Aministered i.p.; twice a day for three weeks Result: Caused a dramatic reduction of tumors in both skeleton and visceral organs.

[References]

[1]. Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14(6):518-27.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H27Cl2N3O

[ Molecular Weight ]:
456.41

Related Compounds