Dehydromonocrotaline
Names
[ CAS No. ]:
23291-96-5
[ Name ]:
Dehydromonocrotaline
[Synonym ]:
|A,|A-Dehydrolovastatin
Dehydro Lovastatin
Dehydromonacolin K
monocrotaline pyrrole
Chemical & Physical Properties
[ Density]:
1.43g/cm3
[ Boiling Point ]:
557ºC at 760mmHg
[ Molecular Formula ]:
C16H21NO6
[ Molecular Weight ]:
323.34100
[ Flash Point ]:
290.6ºC
[ Exact Mass ]:
323.13700
[ PSA ]:
97.99000
[ LogP ]:
0.67100
[ Vapour Pressure ]:
3.06E-13mmHg at 25°C
[ Index of Refraction ]:
1.62
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC1250000
- CHEMICAL NAME :
- 20-Norcrotalanan-11,15-dione, 3,8-didehydro-14,19-dihydro-12,13-dihydroxy-, (13-alpha,14- alpha)-
- CAS REGISTRY NUMBER :
- 23291-96-5
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C16-H21-N-O6
- MOLECULAR WEIGHT :
- 323.38
- WISWESSER LINE NOTATION :
- T55-11- 1A P EN IOV NVO BU FUTJ K1 LQ L1 MQ M1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Liver - other changes
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 12,299,1976
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.97- 1969- Volume(issue)/page/year: 100,169,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 mg/kg/5W-I
- TOXIC EFFECTS :
- Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.97- 1969- Volume(issue)/page/year: 118,121,1976 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1504 mg/kg/47W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- REFERENCE :
- CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 17,61,1982