Nalbuphine Hydrochloride
Names
[ CAS No. ]:
23277-43-2
[ Name ]:
Nalbuphine Hydrochloride
[Synonym ]:
Nalbuphine hydrochloride
17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride hydrate
17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol
Nalbuphine hydrochloride hydrate
(4R,4aS,7S,7aR,12bS)-3-(cyclobutylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol,hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
566.6ºC at 760 mmHg
[ Melting Point ]:
230.5ºC
[ Molecular Formula ]:
C21H28ClNO4
[ Molecular Weight ]:
393.90400
[ Flash Point ]:
296.5ºC
[ Exact Mass ]:
393.17100
[ PSA ]:
73.16000
[ LogP ]:
2.44720
[ Vapour Pressure ]:
1.12E-13mmHg at 25°C
[ Storage condition ]:
?20°C
[ Water Solubility ]:
H2O: soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD3181000
- CHEMICAL NAME :
- Morphinan-3,6-alpha,14-triol, 17-(cyclobutylmethyl)-4,5-alpha-epoxy-, hydrochloride
- CAS REGISTRY NUMBER :
- 23277-43-2
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C21-H27-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 393.95
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 800 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
- REFERENCE :
- CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park Ridge, IL 60068) V.57- 1970- Volume(issue)/page/year: 90,773,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5314 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311-H330-H370
[ Precautionary Statements ]:
P210-P260-P280-P284-P301 + P310-P310
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
26/27/28
[ Safety Phrases ]:
22-36/37/39-45
[ RIDADR ]:
UN 1544
[ RTECS ]:
QD3181000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Am. J. Vet. Res. 72(6) , 741-5, (2011)
To assess the pharmacokinetics of nalbuphine HCl after IV and IM administration to Hispaniolan Amazon parrots (Amazona ventralis).8 healthy adult Hispaniolan Amazon parrots of unknown sex.Nalbuphine H...
A review of systemic opioids commonly used for labor pain relief.J. Midwifery Womens. Health 56(3) , 222-39, (2011)
Parenteral opioids for pain relief during labor have been the subject of research for many decades. Commonly used systemic opioids provide limited pain relief during labor yet are used extensively for...
Ultrasound guidance characteristics and efficiency of suprazygomatic maxillary nerve blocks in infants: a descriptive prospective study.Paediatr. Anaesth. 22(9) , 841-6, (2012)
Bilateral suprazygomatic maxillary nerve blocks approach improves pain relief after palate surgery. We report the feasibility and efficiency of ultrasound-guided suprazygomatic maxillary nerve blocks ...