3,6-Dioxaoctanedioic acid

Names

[ Name ]:
3,6-Dioxaoctanedioic acid

[Synonym ]:
2,2'-(ethane-1,2-diylbis(oxy))diacetic acid
3,6-dioxaoctadioic acid
3,6-dioxoctanedioic acid
3,6-dioxa-1,8-octanedioic acid
3,6-dioxaoctane-1,8-dioic acid
3,6-DIOXAOCTANEDIOIC ACID
(2-carboxymethoxyethoxy)acetic acid
3,6-dioxaoctandioic acid

Biological Activity

[Description]:

36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.375g/cm3

[ Boiling Point ]:
429.2ºC at 760mmHg

[ Melting Point ]:
68-71℃

[ Molecular Formula ]:
C₆H₁₀O₆

[ Molecular Weight ]:
178.14000

[ Flash Point ]:
182.6ºC

[ Exact Mass ]:
178.04800

[ PSA ]:
93.06000

[ Vapour Pressure ]:
1.43E-08mmHg at 25°C

[ Index of Refraction ]:
1.474

[ Storage condition ]:
Store below +30°C.

Safety Information

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
26-36/37/39-45-27-22

[ RIDADR ]:
UN 3261

[ Packaging Group ]:
III

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.