N-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide

Names

[ CAS No. ]:
2322322-23-4

[ Name ]:
N-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide

[Synonym ]:
MFCD31811434

Biological Activity

[Description]:

Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₃N₅O₆

[ Molecular Weight ]:
487.55

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.