(S)-CCG-1423

Names

[ CAS No. ]:
2319939-24-5

[ Name ]:
(S)-CCG-1423

Biological Activity

[Description]:

(S)-CCG-1423 is an inhibitor of Rho signaling that blocks the nuclear import of MRTF-A. (S)-CCG-1423 reduces the nuclear accumulation of MRTF-A and improves glucose uptake and tolerance in insulin-resistance mice in vivo. (S)-CCG-1423 exhibits higher inhibition activity than the SR- and the R-isomers of CCG-1423 (HY-13991). (S)-CCG-1423 can be used for the research of cancer and diabetes[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Signaling Pathways >> GPCR/G Protein >> Ras

Research Areas >> Metabolic Disease

[References]

[1]. Watanabe B, et al. Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. PLoS One. 2015 Aug 21;10(8):e0136242.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₃ClF₆N₂O₃

[ Molecular Weight ]:
454.75

Related Compounds

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