LEI110(LEI-110

Names

[ Name ]:
LEI110(LEI-110

Biological Activity

[Description]:

LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells; LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT).

[References]

References 1. Zhou J, et al. ACS Chem Biol. 2019 Jan 8. doi: 10.1021/acschembio.8b00969. View Related Products by Target Phospholipase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₃F₃N₂O₃

[ Molecular Weight ]:
456.465

Related Compounds

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