TCO-GK-PEG4-NHS ester

Names

[ CAS No. ]:
2307311-19-7

[ Name ]:
TCO-GK-PEG4-NHS ester

Biological Activity

[Description]:

TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[References]

[1]. Zhou Z, et al. An Efficient Method for Labeling Single Domain Antibody Fragments with 18F Using Tetrazine- Trans-Cyclooctene Ligation and a Renal Brush Border Enzyme-Cleavable Linker. Bioconjug Chem. 2018 Dec 19;29(12):4090-4103.  

Chemical & Physical Properties

[ Molecular Formula ]:
C33H52N4O14

[ Molecular Weight ]:
728.78

Related Compounds