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VH 101, phenol

Names

[ CAS No. ]:
2306193-99-5

[ Name ]:
VH 101, phenol

[Synonym ]:
MFCD32201089

Biological Activity

[Description]:

E3 ligase Ligand 19 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 19 can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1]。

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

VHL


[References]

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H33FN4O5S

[ Molecular Weight ]:
532.63

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds