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3-​Oxocholic acid

Names

[ CAS No. ]:
2304-89-4

[ Name ]:
3-​Oxocholic acid

[Synonym ]:
3-OXO DEOXYCHOLIC ACID
3-Oxo-7Alpha,12Alpha-hydroxy-5Beta-cholanoic Acid
7Alpha,12Alpha-dihydroxy-3-oxo-5Beta-cholan-24-oic acid
3-Keto-7alpha,12alpha-dihydroxy-5alpha-cholanic acid
3-Oxo-7α,12α-hydroxy-5β-cholanoic Acid
3-Oxo-7a,12a-dihydroxy-5b-cholanic acid

Biological Activity

[Description]:

3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals[1][2][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vivo]

Male Goto-Kakizaki (GK) rats rats are subjected to Ileal transposition (IT) surgery. In the metabolomics analysis, compared with Sham-IT rats, 3-Oxocholic acid of IT rats is increased[2].

[References]

[1]. Macdonald I, et al. Identification of 7alpha-, 12alpha-dihydroxy-3-oxo cholanoic acid as the major degradation product from cholic by C. perfringens. J Steroid Biochem. 1978 Apr;9(4):353-8.

[2]. Yan K, et al. The Changes of Serum Metabolites in Diabetic GK Rats after Ileal Transposition Surgery. Obes Surg. 2019 Mar;29(3):882-890.

[3]. Wahlström A, et al. Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. Cell Metab. 2016 Jul 12;24(1):41-50.

Chemical & Physical Properties

[ Density]:
1.180±0.06g/ml(Predicted)

[ Boiling Point ]:
583.0±50.0℃(Predicted)

[ Melting Point ]:
185℃

[ Molecular Formula ]:
C24H38O5

[ Molecular Weight ]:
406.55600

[ Exact Mass ]:
406.27200

[ PSA ]:
94.83000

[ LogP ]:
3.65690

[ Vapour Pressure ]:
5.08E-16mmHg at 25°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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