4-Bromoimidazole

Names

[ Name ]:
4-Bromoimidazole

[Synonym ]:
Imidazole,4-bromo
1H-Imidazole,4-bromo
4-Bromoimidazole
4-Bromo-1H-imidazol
MFCD00047021
1H-Imidazole, 5-bromo-
3kqm
4-Bromo-1H-imidazole

Biological Activity

[Description]:

4-Bromo-1H-imidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

用作有机合成、农药、医药、染料等领域的重要原料中间体

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
324.7±15.0 °C at 760 mmHg

[ Melting Point ]:
131-135 °C(lit.)

[ Molecular Formula ]:
C₃H₃BrN₂

[ Molecular Weight ]:
146.97

[ Flash Point ]:
150.2±20.4 °C

[ Exact Mass ]:
145.947952

[ PSA ]:
28.68000

[ LogP ]:
0.97

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.602

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI3517450

CHEMICAL NAME :: 1H-Imidazole, 4-bromo-

CAS REGISTRY NUMBER :: 2302-25-2

LAST UPDATED :: 199609

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C3-H3-Br-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 89,175,1987

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S36-S45-S37/39-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
NI3517450

[ Hazard Class ]:
6.1

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Crystal structure of 4-bromo-1H-imidazole, at 200 K, C₃H₃BrN₂. Hosten EC and Betz R.

Zeitsch. für Kristall. 230(1) , 27-28, (2015)

Efficient synthesis of DNA containing the guanine oxidation-nitration product 5-guanidino-4-nitroimidazole: Generation by a postsynthetic substitution reaction. Neeley WL, et al.

Org. Lett. 6(2) , 245-248, (2004)

Palladium-catalyzed amination of unprotected five-membered heterocyclic bromides. Su M, et al.

Org. Lett. 16(3) , 832-835, (2014)

Related Compounds

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