PROTAC FAK degrader 1

Names

[ CAS No. ]:
2301916-69-6

[ Name ]:
PROTAC FAK degrader 1

Biological Activity

[Description]:

PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK

[Target]

IC50: 6.5 nM (Focal adhesion kinase) DC50: 3 nM (Focal adhesion kinase)[1]

[References]

[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₅₆F₃N₉O₈S₂

[ Molecular Weight ]:
996.13

[ Storage condition ]:
-20°C

Related Compounds

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