Vobasan-17-oic acid,19,20-dihydro-3-oxo-, methyl ester, (20a)-

Names

[ CAS No. ]:
2299-26-5

[ Name ]:
Vobasan-17-oic acid,19,20-dihydro-3-oxo-, methyl ester, (20a)-

[Synonym ]:
3-oxo-19,20-dihydro-vobasan-17-oic acid methyl ester
tabernaemontanine

Chemical & Physical Properties

[ Density]:
1.176g/cm3

[ Boiling Point ]:
515.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₂₆N₂O₃

[ Molecular Weight ]:
354.44300

[ Flash Point ]:
265.8ºC

[ Exact Mass ]:
354.19400

[ PSA ]:
62.40000

[ LogP ]:
2.98030

[ Vapour Pressure ]:
9.47E-11mmHg at 25°C

[ Index of Refraction ]:
1.581

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZB1635000

CHEMICAL NAME :: Vobasan-17-oic acid, 19,20-dihydro-3-oxo-, methyl ester, (20-alpha)-

CAS REGISTRY NUMBER :: 2299-26-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H26-N2-O3

MOLECULAR WEIGHT :: 354.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 28,697,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 28,697,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 28,697,1970

Related Compounds

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