Enpp-1-IN-17

Names

[ CAS No. ]:
2289736-54-3

[ Name ]:
Enpp-1-IN-17

Biological Activity

[Description]:

Enpp-1-IN-17 (example 274) is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. The selectivity ratio for inhibition of cGAMP hydrolysis versus ATP hydrolysis is >6.4[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Infection

[References]

[1]. William Michael Gallatin, et al. Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof. Patent, WO2019046778A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H24N4O2

[ Molecular Weight ]:
328.41

Related Compounds

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