(E/Z)-E64FC26

Names

[ Name ]:
(E/Z)-E64FC26

Biological Activity

[Description]:

(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1.

[2]. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₃F₃O₂

[ Molecular Weight ]:
340.38

Related Compounds

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