Taltobulin intermediate-1

Names

[ Name ]:
Taltobulin intermediate-1

[Synonym ]:
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N,β,β-trimethyl-
N,β,β-Trimethyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-phenylalanine

Biological Activity

[Description]:

Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

Chemical & Physical Properties

[ Density]:
1.107±0.06 g/cm3(Predicted)

[ Boiling Point ]:
419.6±34.0 °C(Predicted)

[ Molecular Formula ]:
C₁₇H₂₅NO₄

[ Molecular Weight ]:
307.39

[ Flash Point ]:
207.6±25.7 °C

[ Exact Mass ]:
307.178345

[ LogP ]:
4.15

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.518

Related Compounds

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