Protein kinase inhibitor 4

Names

[ CAS No. ]:
2278205-04-0

[ Name ]:
Protein kinase inhibitor 4

Biological Activity

[Description]:

Protein kinase inhibitor 4 (Compound 3) is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

[Target]

IC50: 3.0 nM (Trk-A), 104 nM (ROS-1)[1]


[References]

[1]. Dawei Zhang, et al. Substituted pyrazolopyrimidines useful as kinases inhibitors. Patent. WO2019029629A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24F2N6O3S

[ Molecular Weight ]:
526.56

Related Compounds