NDI-034858

Names

[ CAS No. ]:
2272904-53-5

[ Name ]:
NDI-034858

Biological Activity

[Description]:

NDI-034858 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

Tyk2 JH2 domain[1]

[In Vitro]

NDI-034858 (compound I-908) (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1]. NDI-034858 inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell[1].

[References]

[1]. Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₄N₈O₃

[ Molecular Weight ]:
460.49

NDI-034858

Names

Biological Activity

Chemical & Physical Properties

Related Compounds