monoethanolamine oleate

Names

[ Name ]:
monoethanolamine oleate

[Synonym ]:
Neosclerol
Monolate
Ethamolin
Moramin
Monoethanolamine oleate
ETHANOLAMINE OLEATE
Oldamin
Varicetin
Varex

Biological Activity

[Description]:

Oleic (9-cis-Octadecenoic) acid ethanolamine consists of oleic acid and ethanolamine. Oleic acid ethanolamine has sclerotherapeutic activity. Oleic acid ethanolamine can cause inflammatory reaction in the intimal endothelium of the vein[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

Inflammation[1]

[References]

[1]. Kiripolsky MG. More on ethanolamine oleate as a vascular sclerosant. Dermatol Surg. 2010 Jul;36(7):1153-4.

Chemical & Physical Properties

[ Density]:
0.973g/cm3

[ Boiling Point ]:
170.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₄₁NO₃

[ Molecular Weight ]:
343.54400

[ Flash Point ]:
93.3ºC

[ Exact Mass ]:
343.30900

[ PSA ]:
83.55000

[ LogP ]:
5.74620

[ Vapour Pressure ]:
3.7E-06mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG2900000

CAS REGISTRY NUMBER :: 2272-11-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H34-O2.C2-H7-N-O

MOLECULAR WEIGHT :: 343.62

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 156 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 17,357,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 17,373,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1228 No. of Facilities: 1996 (estimated) No. of Industries: 22 No. of Occupations: 31 No. of Employees: 40126 (estimated) No. of Female Employees: 2760 (estimated)

Safety Information

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%