Icapamespib HCl

Names

[ Name ]:
Icapamespib HCl

Biological Activity

[Description]:

Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₅Cl₂IN₆O₂S

[ Molecular Weight ]:
599.31

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.