Ep300/CREBBP-IN-4

Ep300/CREBBP-IN-4 (Example 56) is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. Ep300/CREBBP-IN-4 can be used for the research of cancer[1].

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

EP300:0.024 μM (IC50)

CREBBP:0.064 μM (IC50)

Ep300/CREBBP-IN-4 (Example 56) 抑制细胞内 H3K27Ac 活性，其 IC50 为 0.020 μM[1]。 Ep300/CREBBP-IN-4 (38 nM-10 mM; 3 days) 抑制 LK2 和 TE-8 细胞生长，GI50 分别为 98.803 μM 和 88.333 μM [1]。 Cell Viability Assay[1] Cell Line: LK2 and TE-8 cells Concentration: 38 nM-10 mM Incubation Time: 3 days Result: Inhibited LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively.

[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.