Robustine

Names

[ Name ]:
Robustine

[Synonym ]:
4-Methoxyfuro[2,3-b]quinolin-8-ol
8-hydroxydictamnine
8-Hydroxy-4-methoxy-furo<2,3-b>chinolin
Furo[2,3-b]quinolin-8-ol, 4-methoxy-
8-Hydroxydictamnin
Robustine

Biological Activity

[Description]:

Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[Target]

PDE5A

[References]

[1]. Nam KW, et al. Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro. Arch Pharm Res. 2005 Jun;28(6):675-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
411.9±40.0 °C at 760 mmHg

[ Melting Point ]:
148-149℃ (ethanol )

[ Molecular Formula ]:
C₁₂H₉NO₃

[ Molecular Weight ]:
215.205

[ Flash Point ]:
202.9±27.3 °C

[ Exact Mass ]:
215.058243

[ PSA ]:
55.49000

[ LogP ]:
2.73

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.708

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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