JWG-071

Names

[ Name ]:
JWG-071

Biological Activity

[Description]:

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

ERK5:88 nM (IC50)

[In Vitro]

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].

[References]

[1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₄₄N₈O₃

[ Molecular Weight ]:
612.76

Related Compounds

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