Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine

Names

[ CAS No. ]:
2249935-19-9

[ Name ]:
Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine

Biological Activity

[Description]:

Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine is an immune stimulator antibody conjugate (ISAC) comprising an anti-human epidermal growth factor receptor 2 (HER2) antibody, a STING agonist (ADU-S100) and a linker. Mal-VC-PAB-(N-Me-amide-C3)-ADU-S100 triethylamine can be uesd for cancer research (WO2018200812A1; example 5)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Signaling Pathways >> Immunology/Inflammation >> STING

[Target]

HER2


[In Vitro]

STING（干扰素基因刺激物）是一种促进先天免疫信号传导的内质网衔接子。据报道，STING 包含四个假定的跨膜区域，主要位于内质网中，能够激活 NF-kB、STAT6 和 IRF3 转录途径以诱导 I 型干扰素 (例如 IFN-α 和 IFN-β) 的表达 并在表达后发挥有效的抗病毒状态。相反，STING 的缺失使小鼠胚胎成纤维细胞极易受到负链病毒感染，包括水疱性口炎病毒[1]。

[References]

[1]. Thomas W. Dubensky Jr., et al. Antibody conjugates comprising sting agonist. WO2018200812A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C51H65N17O19P2S2.xC6H15N

Related Compounds