HP1328

Names

[ Name ]:
HP1328

Biological Activity

[Description]:

HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[References]

[1]. Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65(4):3597-3605.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₃N₃O₃

[ Molecular Weight ]:
389.45

Related Compounds

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