BAY-293 racemate
Names
[ CAS No. ]:
2244904-14-9
[ Name ]:
BAY-293 racemate
Biological Activity
[Description]:
BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).
[References]
References 1. Hillig RC, et al. Proc Natl Acad Sci U S A. 2019 Jan 25. pii: 201812963. doi: 10.1073/pnas.1812963116. View Related Products by Target Ras
Chemical & Physical Properties
[ Molecular Formula ]:
C25H28N4O2S
[ Molecular Weight ]:
448.585