IDH1 Inhibitor 2

Names

[ CAS No. ]:
2244895-42-7

[ Name ]:
IDH1 Inhibitor 2

Biological Activity

[Description]:

IDH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)

[Target]

IC50: 110 nM (IDH1)[1].

[References]

[1]. Jakob CG, et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018 Aug 9;61(15):6647-6657.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₂N₄O

[ Molecular Weight ]:
406.48

Related Compounds

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