URAT1 inhibitor 6

Names

[ CAS No. ]:
2244807-49-4

[ Name ]:
URAT1 inhibitor 6

Biological Activity

[Description]:

URAT1 inhibitor 6 (Compound 1h) is a potent URAT1 inhibitor (IC50: 35 nM for hURAT1). URAT1 inhibitor 6 is 200- and 8-fold more potent than parent Lesinurad (HY-15258) and Benzbromarone (HY-B1135). URAT1 inhibitor 6 can be used for research of inflammation[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1
Research Areas >> Inflammation/Immunology

[References]

[1]. Cai W, et al. Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor. Molecules. 2018 Jan 27;23(2):252.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H7BrN3NaO2S2

[ Molecular Weight ]:
356.19

Related Compounds