DBCO-PEG4-Val-Cit-PAB-MMAF

Names

[ Name ]:
DBCO-PEG4-Val-Cit-PAB-MMAF

Biological Activity

[Description]:

DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Auristatin

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₈H₁₂₆N₁₂O₂₀

[ Molecular Weight ]:
1672.01

Related Compounds

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