DM-CO-(CH2)5-SMe

Names

[ CAS No. ]:
2243689-84-9

[ Name ]:
DM-CO-(CH2)5-SMe

Biological Activity

[Description]:

DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

DM-CO-(CH2)5-SMe (0.00008-30 nM；5 d) 抑制 H1703、H1975、COLO704 和 Colo720E 细胞的活性，IC50 值分别为 2.27 pM、0.893 pM、3.04 pM 和 3 pM[1]。

[References]

[1]. Widdison, et al. Preparation of maytansinoid derivatives with self-immolative peptide linkers and their conjugates as antitumor agents. World Intellectual Property Organization. WO2018160539.

Chemical & Physical Properties

[ Molecular Formula ]:
C39H56ClN3O10S

[ Molecular Weight ]:
794.39

Related Compounds