ABN401

Names

[ Name ]:
ABN401

Biological Activity

[Description]:

ABN401 is a highly potent and selective ATP-competitive c-MET inhibitor with an IC50 value of 10 nM. ABN401 has cytotoxic activity against MET-addicted cancer cells. ABN401 can inhibit c-MET phosphorylation in tumor tissues. ABN401 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[Target]

IC50: 10 nM (c-MET)[1]

[References]

[1]. Kim J, et al. Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer. Cancers (Basel). 2020;12(6):1575. Published 2020 Jun 15.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₄N₁₂O

[ Molecular Weight ]:
566.66

Related Compounds

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