methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate

Names

[ CAS No. ]:
22425-82-7

[ Name ]:
methyl (4aS,6aR,6aS,6bR,10R,11R,12aR,14bR)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate

[Synonym ]:
Crategolic acid methyl ester
Methyl maslinate
Maslinic acid methyl ester
2alpha,3beta-Dihydroxyolean-12-en-28-oic acid methyl ester

Biological Activity

[Description]:

Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vivo]

Methyl maslinate (MM) (20-60 mg/kg; i.p.) shows significant, dose-dependent vasodepressor effect and sinus bradycardia, lasting more than 60 minutes with a maximum at 20 minutes, and shows potent hymodynamic effect[1]. Methyl maslinate (40 mg/kg) shows antidysrhythmic activity on ischemia-reperfusion dysrhythmia[1]. Animal Model: Wistar male rats (300-320 g)[1] Dosage: 20-60 mg/kg Administration: Intraperitoneal injection; once Result: Showed significant, dose-response vasodepressor effect and sinus bradicardia. Antagonized β-Adrenergic. Showed antidysrhythmic activity.

[References]

[1]. Somova LI, et al. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine. 2004 Feb;11(2-3):121-9.

Chemical & Physical Properties

[ Density]:
1.11g/cm3

[ Boiling Point ]:
541.9ºC at 760mmHg

[ Molecular Formula ]:
C31H50O4

[ Molecular Weight ]:
486.72600

[ Flash Point ]:
163.1ºC

[ Exact Mass ]:
486.37100

[ PSA ]:
66.76000

[ LogP ]:
6.29280

[ Vapour Pressure ]:
5.29E-14mmHg at 25°C

[ Index of Refraction ]:
1.552

Precursor & DownStream

Precursor

DownStream