Anticancer agent 147

Names

[ CAS No. ]:
2241283-11-2

[ Name ]:
Anticancer agent 147

Biological Activity

[Description]:

Anticancer agent 147 (compound 6j) is a derivative of sophoridine (HY-N1373) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe2+, reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Ferroptosis

[References]

[1]. Tian K, et al. Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis. Cell Death Discov. 2023 Aug 14;9(1):296..  

Chemical & Physical Properties

[ Molecular Formula ]:
C32H40BrN3O2

[ Molecular Weight ]:
578.58

Related Compounds

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