NLRP3-IN-19

Names

[ Name ]:
NLRP3-IN-19

Biological Activity

[Description]:

JT001 (NLRP3-IN-19) is a potent, specific and orally active inhibitor of NLRP3. JT001 can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 can be used for the research of nonalcoholic steatohepatitis and liver fibrosis[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

Research Areas >> Inflammation/Immunology

[Target]

NLRP3

[References]

[1]. Povero D, et, al. Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂N₄O₄S

[ Molecular Weight ]:
402.47

Related Compounds

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