EP1013

Names

[ CAS No. ]:
223568-55-6

[ Name ]:
EP1013

[Synonym ]:
Pentanoic acid, 5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-, (3S)-
(3S)-3-({N-[(Benzyloxy)carbonyl]-L-valyl}amino)-5-fluoro-4-oxopentanoic acid

Biological Activity

[Description]:

EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Metabolic Disease

[Target]

Caspase


[In Vivo]

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].

[References]

[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.


[Related Small Molecules]

Z-VAD(OMe)-FMK | VX-765 | QVD-OPh | Z-DEVD-FMK | Z-IETD-FMK | Sodium tauroursodeoxycholate | Ac-DEVD-CHO | Emricasan | PAC-1 | BOC-D-FMK | Taurochenodeoxycholic acid | 20(S)-Ginsenoside Rh2 | 2-HBA | Biotin-VAD-FMK | Ginsenoside Rh4

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
639.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H23FN2O6

[ Molecular Weight ]:
382.383

[ Flash Point ]:
340.7±31.5 °C

[ Exact Mass ]:
382.154022

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
2-8℃