2-Pentanone, 5-phenyl-

Names

[ Name ]:
2-Pentanone, 5-phenyl-

[Synonym ]:
5-phenyl-pentan-2-one
methyl 3-phenylpropyl ketone
1-phenyl-4-pentanone
5-PHENYL-2-PENTANONE
2-Pentanone,5-phenyl
5-Phenyl-pentan-2-on

Biological Activity

[Description]:

Phenylbutyrate is a potent histone deacetylases (HDACs) inhibitor. Phenylbutyrate can be used for urea cycle disorder research[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Sabrina Paganoni, et al. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis. N Engl J Med. 2020 Sep 3;383(10):919-930.

[2]. Sabbir Khan, et al. Phenylbutyrate and β-cell function: contribution of histone deacetylases and ER stress inhibition.

Chemical & Physical Properties

[ Density]:
0.96g/cm3

[ Boiling Point ]:
261.2ºC at 760mmHg

[ Melting Point ]:
106-107 °C

[ Molecular Formula ]:
C₁₁H₁₄O

[ Molecular Weight ]:
162.22800

[ Flash Point ]:
121.5ºC

[ Exact Mass ]:
162.10400

[ PSA ]:
17.07000

[ LogP ]:
2.59830

[ Vapour Pressure ]:
0.0117mmHg at 25°C

[ Index of Refraction ]:
1.5

Safety Information

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Related Compounds

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