DS88790512

Names

[ CAS No. ]:
2231089-95-3

[ Name ]:
DS88790512

Biological Activity

[Description]:

DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cardiovascular Disease

[Target]

IC50: 11 nM (TRPC6)[1]

[References]

[1]. Motoyama K, et al. Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6). Bioorg Med Chem Lett. 2018 Jul 1;28(12):2222-2227.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₉N₃O₂

[ Molecular Weight ]:
367.48

Related Compounds

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