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PROTAC FLT-3 degrader 1

Names

[ CAS No. ]:
2230826-81-8

[ Name ]:
PROTAC FLT-3 degrader 1

Biological Activity

[Description]:

PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC

[Target]

IC50: 0.6 nM (FLT-3 ITD)[1]


[References]

[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.

Chemical & Physical Properties

[ Molecular Formula ]:
C52H61N9O9S2

[ Molecular Weight ]:
1020.23

[ Storage condition ]:
-20°C

Related Compounds