(R,S,S)-VH032

Names

[ Name ]:
(R,S,S)-VH032

Biological Activity

[Description]:

(R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

VHL[1]

[References]

[1]. Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11(11):5279-5295.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₀N₄O₃S

[ Molecular Weight ]:
430.56

[ Storage condition ]:
2-8°C

Related Compounds

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