ZL0454

Names

[ Name ]:
ZL0454

Biological Activity

[Description]:

ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

IC50: 49 nM nM (BD1), 32 nM nM (BD2)[1]

[References]

[1]. Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₂N₄O₃S

[ Molecular Weight ]:
374.46

Related Compounds

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