AZ-3

Names

[ CAS No. ]:
2228908-91-4

[ Name ]:
AZ-3

Biological Activity

[Description]:

AZ-3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

IC50: 34 nM (JAK1)[1]

[References]

[1]. Grimster NP, et al. Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors. J Med Chem. 2018 Jun 28;61(12):5235-5244.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₈FN₇

[ Molecular Weight ]:
385.48

Related Compounds

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