NaPi2b-IN-2

Names

[ Name ]:
NaPi2b-IN-2

Biological Activity

[Description]:

NaPi2b-IN-2 (compound 5) is a potent inhibitor of sodium-dependent transport protein 2b (SLC34A2, NaPi2b), with an IC50 of 38 nM for human NaPi2b. NaPi2b-IN-2 can be used for the research of hyperphosphatemia[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: 38 nM (human NaPi2b)[1]

[References]

[1]. Ushiki Y, et, al. Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem Lett. 2022 Mar 1;59:128572.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₁H₄₇ClF₃N₅O₅S

[ Molecular Weight ]:
814.36

Related Compounds

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