NaPi2b-IN-3

NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia[1].

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent[1]. Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats[1]. IV (1 mg/kg) PO (10 mg/kg) AUC0-t (h·ng/mL) 834 ± 353 1090 ± 430 Cmax (ng/mL) 568 ± 261 F (%) 13.1 Animal Model: Sprague-Dawley rats[1] Dosage: 1 and 10 mg/kg Administration: IV and PO; single dosage Result: Exhibited good activity and moderate hydrophobicity and systemically exposed to some extent.

[1]. Ushiki Y, et al. Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors. Bioorg Med Chem. 2022;66:116783.